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Non-invasive optical control of endogenous Ca2+ channels in awake mice

Kim S, Kyung T, Chung JH, Kim N, Keum S, Lee J, Park H, Kim HM, Lee S, Shin HS, Heo WD.  Nat. Comm. 2020. 11:210.


Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy

Keum S and Shin HS. Neuron. 2019 104(1):78-86.

Genetic factors associated with empathy in humans and mice

Keum S and Shin HS. Neuropharmacology. 2019. pii: S0028-3908(19)30029-2.

Observational fear behavior in rodents as a model for empathy

Kim A, Keum S, Shin HS. Genes Brain Behav. 2019. 18(1):e12521.


A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse

Keum S*, Kim A*, Shin JJ, Kim JH, Park J, Shin HS. Neuron. 2018. 98(3): 588-601. 

- This paper has been selected as a featured article and highlighted in Neuron by a preview article by Dr. Gloria Choi.

- This article has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Dr. Louis F Reichard.


Rodent models for studying empathy

Keum S and Shin HS. Neurobiol Learn Mem. 2016. 135: 22-26.

Variability in empathic fear response among 11 inbred strains of mice

Keum S, Park J, Kim A, Park J, Kim KK, Jeong J, Shin HS. Genes Brain Behav. 2016. 15(2): 231-42.

[Before  Joining IBS]

McClung JM, McCord TJ, Ryan TE, Schmidt CA, Green TD, Southerland KW, Reinardy JL, Mueller SB, Venkatraman TN, Lascola CD, Keum S, Marchuk DA, Spangenburg EE, Dokun AO, Annex BH, Kontos CD. A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. Circulation. 2017. 136(3): 281-296.

Lee HK, Keum S, Sheng H, Warner DS, Lo DC, Marchuk DA. Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. J Clin Invest. 2016. 126(8): 2827-38.

Keum S, Lee HK, Chu PL, Kan MJ, Huang MN, Gallione CJ, Gunn MD, Lo DC, Marchuk DA. Natural Genetic Variation of Integrin alpha L (Itgal) Modulates Ischemic Brain Injury in Stroke. PLoS Genet. 2013. 9(10): e1003807.

Chu PC, Keum S, Marchuk DA. A Novel Genetic Locus Modulates Infarct Volume Independent Of the Extent Of Collateral Circulation. Physiol Genomics. 2013. 45(17): 751-63.

McClung JM, McCord TJ, Keum S, Marchuk DA, Bowles D, Annex BH, Johnson S, Kontos CD. Differential Limb Vascular and Muscle Cell Response to Insult Determines Strain Dependent Pathology with Ischemia. Am J Pathol. 2012. 180(5): 2156-69.


Ahn SH, Deshmukh H, Johnson N, Cowell LG, Rude TH, Scott WK, Nelson CL, Zaas AK, Marchuk DA, Keum S, Lamlertthon S, Sharma-Kuinkel BK, Sempowski GD, and Fowler VG.  Two Genes on A/J Chromosome 18 are Associated with Susceptibility to Staphylococcus aureus Infection by Combined Microarray and Quantitative Trait Locus (QTL) Analyses. PLoS Pathog. 2010. 6(9): e1001088.

Zhang H, Keum S, Marchuk DA, Sealock R, Faber JE. Analysis of 19 mouse strains demonstrates that genetic variations in pial collateral dimensions are the major determinants of severity of infarct volume after middle cerebral artery occlusion (MCAO). Cardiovasc Revasc Med. 2009.10(4): 273-274.


Keum S and Marchuk DA.  A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. Circ Cardiovas Genet. 2009. 2:591-598.

Dokun AO*, Keum S*, Hazarika S, Li Y, LaMonte GM, Wheeler F, Marchuk DA, Annex BH.  A QTL (LSq-1) on mouse chromosome 7 is linked to prevention of tissue loss following surgical hind-limb ischemia. Circulation. 2008. 117(9): 1207-15.

Kim D, Song I, Keum S, Lee T, Jeong MJ, Kim SS, McEnery MW, Shin HS.  Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca2+ channels. Neuron. 2001. 31(1): 35-45.

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